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- Title
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
- Authors
Velazquez-Torres, Guermarie; Shoshan, Einav; Ivan, Cristina; Li Huang; Fuentes-Mattei, Enrique; Paret, Harrison; Sun Jin Kim; Rodriguez-Aguayo, Cristian; Xie, Victoria; Brooks, Denise; Jones, Steven J. M.; Gordon Robertson, A.; Calin, George; Lopez-Berenstein, Gabriel; Sood, Anil; Bar-Eli, Menashe
- Abstract
Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.
- Subjects
MELANOMA; RNA editing; CELL lines; CELL tumors; EDITING; MICROPHTHALMIA-associated transcription factor
- Publication
Nature Communications, 2018, Vol 9, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-018-02851-7