We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
β-cell mass and turnover in humans: effects of obesity and aging.
- Authors
Saisho Y; Butler AE; Manesso E; Elashoff D; Rizza RA; Butler PC; Saisho, Yoshifumi; Butler, Alexandra E; Manesso, Erica; Elashoff, David; Rizza, Robert A; Butler, Peter C
- Abstract
<bold>Objective: </bold>We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age.<bold>Research Design and Methods: </bold>We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects.<bold>Results: </bold>β-Cell mass is increased by ~50% with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age.<bold>Conclusions: </bold>β-Cell mass in human obesity increases by ~50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.
- Publication
Diabetes Care, 2013, Vol 36, Issue 1, p111
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc12-0421