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- Title
Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.
- Authors
Michelakis, Evangelos D.; Gurtu, Vikram; Webster, Linda; Barnes, Gareth; Watson, Geoffrey; Howard, Luke; Cupitt, John; Paterson, Ian; Thompson, Richard B.; Chow, Kelvin; O'Regan, Declan P.; Lan Zhao; Wharton, John; Kiely, David G.; Kinnaird, Adam; Boukouris, Aristeidis E.; White, Chris; Nagendran, Jayan; Freed, Darren H.; Wort, Stephen J.
- Abstract
The article discusses study revealing improvement in pulmonary arterial hypertension (PAH) in genetically susceptible patients with inhibition of pyruvate dehydrogenase kinase. Topics discussed include mitochondrial suppression leading to inhibition of apoptosis and downstream signalling promoting proliferation; treatment of explanted human PAH lungs with the PDK inhibitor dichloroacetate (DCA) and lack of ex vivo and clinical response.
- Subjects
PULMONARY artery; HYPERTENSION; PYRUVATE dehydrogenase kinase; ENZYME inhibitors; APOPTOSIS inhibition
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 413, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aao4583