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- Title
Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure.
- Authors
Ning Li; Hansen, Brian J.; Csepe, Thomas A.; Jichao Zhao; Ignozzi, Anthony J.; Sul, Lidiya V.; Zakharkin, Stanislav O.; Kalyanasundaram, Anuradha; Davis, Jonathan P.; Biesiadecki, Brandon J.; Kilic, Ahmet; Janssen, Paul M. L.; Mohler, Peter J.; Weiss, Raul; Hummel, John D.; Fedorov, Vadim V.
- Abstract
The article discusses a study that hypothesized that intranodal pacemakers and sinoatrial conduction pathways with redundant functions have diverse sensitivities to physiologic and pathophysiologic perturbations. Study highlights include the impact of sequential drug applications on sinus rhythm in individual human hearts, intranodal leading pacemaker and conduction in the human sinoatrial node (SAN), and robustness of SAN automaticity and conduction challenged by adenosine.
- Subjects
CARDIAC pacemakers; SINOATRIAL node; ADENOSINES; HEART physiology; HEART conduction system
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 400, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aam5607