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- Title
Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA.
- Authors
Scherer, Florian; Kurtz, David M.; Newman, Aaron M.; Stehr, Henning; Craig, Alexander F. M.; Esfahani, Mohammad Shahrokh; Lovejoy, Alexander F.; Chabon, Jacob J.; Klass, Daniel M.; Chih Long Liu; Li Zhou; Cynthia Glover; Visser, Brendan C.; Poultsides, George A.; Advani, Ranjana H.; Maeda, Lauren S.; Gupta, Neel K.; Levy, Ronald; Ohgami, Robert S.; Kunder, Christian A.
- Abstract
The article discusses a study on diversity in tumor behavior and outcomes exhibited by patients with diffuse large B cell lymphoma (DLBCL). The study employed cancer personalized profiling by deep sequencing (CAPP-Seq) analysis to address the hypothesis about characterization of mutational heterogeneity and genomic evolution. The results showed biological factors that underlie lymphoma clinical outcomes and could facilitate individualized therapy of diffuse large B cell lymphoma (DLBCL).
- Subjects
B cell lymphoma; LYMPHOMAS; NUCLEOTIDE sequencing; CANCER genetics; LYMPHOMA treatment; HUMAN genome
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 364, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aai8545