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- Title
Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique.
- Authors
Wenxiang Dong; Xitong Su; Meng Xu; Mingming Hu; Yinghua Sun; Peng Zhang
- Abstract
Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorvastatin calcium was prepared through the solvent evaporation method, with Poloxamer 188 as hydrophilic carriers. This formulation was then characterized by scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction and fourier transform infrared spectroscopy. Moreover, all these studies suggested the conversion of crystalline atorvastatin calcium. In addition, the drug solubility studies as well as dissolution rates compared with bulk drug and market tablets Lipitor were also examined. Furthermore, the study investigated the pharmacokinetics after oral administration of Lipitor and solid dispersion. And the AUC 0-8 h and C max increased after taking ATC-P188 solid dispersion orally compared with that of Lipitor. All these could be demonstrated that ATC-P188 solid dispersions would be prospective means for enhancing higher oral bioavailability of ATC.
- Subjects
ATORVASTATIN; BIOAVAILABILITY; POLOXAMERS; ORAL medication; DRUG solubility
- Publication
Asian Journal of Pharmaceutical Sciences, 2018, Vol 13, Issue 6, p546
- ISSN
1818-0876
- Publication type
Article
- DOI
10.1016/j.ajps.2018.08.010