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- Title
Malignant melanoma arising in a blue nevus with features of pilar neurocristic hamartoma.
- Authors
Pathy, Arun L.; Helm, Thomas N.; Elston, Dirk; Bergfeld, Wilma F.; Tuthill, Ralph J.
- Abstract
A 65-year-old man presented with a history of a giant blue plaque of the parietal scalp since childhood. Biopsy revealed a cellular blue nevus. The blue nevus was observed for 10 years and thought to be unchanged until a new adjacent lesion was noted. Biopsy of the new lesion revealed metastatic malignant melanoma. A wide excision was performed of the original lesion which revealed malignant melanoma arising in a blue nevus. Areas within the blue nevus were consistent with a pilar neuroscristic hamartoma, whereas other areas were consistent with a common blue nevus. Subsequent satellite metastases developed, with early metastases resembling blue nevi except for the absence of a stromal component and the presence of hyperchromatic nuclei. Later metastases were typical of metastiatic melanoma. This case illustrates the uncommon evolution of malignant melanoma from a blue nevus. The histological features and relationship between melanoma, blue nevus, and pilar neurocristic hamartoma are reviewed.
- Subjects
MELANOMA; NEVUS; CHILDREN; BIOPSY; SURGICAL excision; NEUROENDOCRINE tumors
- Publication
Journal of Cutaneous Pathology, 1993, Vol 20, Issue 5, p459
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1993.tb00672.x