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- Title
The association between trypsin‐like protease activity in the oral cavity and kidney function in Japanese workers.
- Authors
Iwasaki, Masanori; Inoue, Maki; Usui, Michihiko; Ariyoshi, Wataru; Nakashima, Keisuke; Nagai‐Yoshioka, Yoshie; Nishihara, Tatsuji
- Abstract
Aim: To evaluate the association between trypsin‐like protease (TLP) activity in the oral cavity as an indicator of periodontal health status and kidney function in Japanese workers. Materials and Methods: This cross‐sectional study included 1117 Japanese workers (mean age = 43.8 years). Tongue‐swab TLP activity was quantified as a* value (the redness intensity of the matrix disc of the TLP activity assessment kit; a larger value indicates more intense enzymatic activity in the samples and poorer periodontal health status). Kidney function was assessed using the estimated glomerular filtration rate (eGFR; a lower value indicates poorer kidney function). We performed ordinal logistic regression analyses to assess the association of the a* value with three eGFR categories: ≥90, 60–89 and <60 mL/min/1.73 m2. Results: The prevalence for each eGFR category was as follows: ≥90 (31.6%), 60–89 (63.8%) and <60 mL/min/1.73 m2 (4.6%). After adjusting for potential confounders, the a* value was found to be significantly associated with reduced kidney function. The multivariable‐adjusted odds ratio (95% confidence interval) for reduced kidney function was 1.12 (1.02–1.22) per unit increase in the a* value. Conclusions: Higher TLP activity was associated with reduced kidney function in Japanese workers.
- Subjects
JAPAN; TRYPSIN; BIOMARKERS; GLOMERULAR filtration rate; CHRONIC kidney failure; PERIODONTIUM; KIDNEY function tests; CONFIDENCE intervals; ORAL health; PERIODONTITIS; CROSS-sectional method; MEDICAL screening; TONGUE; PROTEOLYTIC enzymes; HEALTH status indicators; RISK assessment; DESCRIPTIVE statistics; RESEARCH funding; LOGISTIC regression analysis; ODDS ratio; DISEASE risk factors; DISEASE complications
- Publication
Journal of Clinical Periodontology, 2024, Vol 51, Issue 3, p265
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.13908