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- Title
Group B streptococcal infection of the genitourinary tract in pregnant and non‐pregnant patients with diabetes mellitus: An immunocompromised host or something more?
- Authors
Nguyen, Lynsa M.; Omage, Joel I.; Noble, Kristen; McNew, Kelsey L.; Moore, Daniel J.; Aronoff, David M.; Doster, Ryan S.
- Abstract
Group B Streptococcus (GBS), also known as Streptococcus agalactiae is a Gram‐positive bacterium commonly encountered as part of the microbiota within the human gastrointestinal tract. A common cause of infections during pregnancy, GBS is responsible for invasive diseases ranging from urinary tract infections to chorioamnionitis and neonatal sepsis. Diabetes mellitus (DM) is a chronic disease resulting from impaired regulation of blood glucose levels. The incidence of DM has steadily increased worldwide to affecting over 450 million people. Poorly controlled DM is associated with multiple health comorbidities including an increased risk for infection. Epidemiologic studies have clearly demonstrated that DM correlates with an increased risk for invasive GBS infections, including skin and soft tissue infections and sepsis in non‐pregnant adults. However, the impact of DM on risk for invasive GBS urogenital infections, particularly during the already vulnerable time of pregnancy, is less clear. We review the evolving epidemiology, immunology, and pathophysiology of GBS urogenital infections including rectovaginal colonization during pregnancy, neonatal infections of infants exposed to DM in utero, and urinary tract infections in pregnant and non‐pregnant adults in the context of DM and highlight in vitro studies examining why DM might increase risk for GBS urogenital infection.
- Subjects
NEONATAL sepsis; STREPTOCOCCAL diseases; SOFT tissue infections; URINARY tract infections; NEONATAL infections; DIABETES
- Publication
American Journal of Reproductive Immunology, 2021, Vol 86, Issue 6, p1
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.13501