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- Title
Avoidance memory requires CaMKII activity to persist after recall.
- Authors
Radiske, Andressa; Gonzalez, Maria Carolina; Rossato, Janine I.; Apolinário, Gênedy; de Oliveira, João R.; Bevilaqua, Lia R. M.; Cammarota, Martín
- Abstract
Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.
- Subjects
LABORATORY rats; PROTEIN kinases; MEMORY; ADULTS
- Publication
Molecular Brain, 2021, Vol 14, Issue 1, p1
- ISSN
1756-6606
- Publication type
Article
- DOI
10.1186/s13041-021-00877-5