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- Title
Interspecies comparison of stellate cell-containing macula flavae and vitamin A storage in vocal fold mucosa.
- Authors
Toya, Yutaka; Riabroy, Napaporn; Davis, Christopher R.; Kishimoto, Yo; Tanumihardjo, Sherry A.; Bless, Diane M.; Welham, Nathan V.
- Abstract
The macula flavae (MF), populated by vitamin A-storing stellate cells (SCs), are believed to play a fundamental role in development, maintenance and repair of the vocal fold (VF) mucosa; however, to date, they have mostly been examined in observational human cadaver studies. Here, we conducted an interspecies comparison of MF and SC phenotype, as well as vitamin A quantification and localization, in human, pig, dog, rabbit and rat VF mucosae. MF containing vitamin A-positive SCs were only identified in human and rat specimens. Pig, dog and rabbit VF mucosae contained no discernable MF, but rather exhibited preferential vitamin A localization to mucous (pig), serous (dog) or mixed (rabbit) glands. This glandular vitamin A storage corresponded to exceedingly high concentrations of retinol in pig and dog mucosae, and retinyl ester in dog mucosa. These findings have significant implications for the presumed role of the MF and SCs in VF biology, the nature of vitamin A storage within the VF mucosa, and the selection of an appropriate animal model for future experimental studies.
- Subjects
RETINYL esters; VITAMIN A; GLIAL fibrillary acidic protein; VOCAL cords; HIGH performance liquid chromatography; GOLD chloride
- Publication
Journal of Anatomy, 2014, Vol 225, Issue 3, p298
- ISSN
0021-8782
- Publication type
Article
- DOI
10.1111/joa.12211