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- Title
Oxymatrine Ameliorates l-Arginine-Induced Acute Pancreatitis in Rats.
- Authors
Zhang, Zhiqiang; Wang, Yanqing; Dong, Ming; Cui, Jianchun; Rong, Daqing; Dong, Qi
- Abstract
The aim of this study was to determine whether oxymatrine has a protective effect against acute pancreatitis (AP) in a rat model of l-arginine-induced AP. AP was induced by two intraperitoneal injections of l-arginine (250 mg/100 g) at a 1-h interval. Oxymatrine (50 mg/kg) was administered every 6 h after the induction of AP. Oxymatrine significantly reduced the plasma amylase, d-lactic acid and tumor necrosis factor alpha concentration, serum diamine oxidase and lipase activity, and pancreatic myeloperoxidase activity, which were increased in AP rats ( P < 0.05). In addition, the pancreatic CD45 expression and the expression of claudin-1, but not zonula occludens-1 (ZO-1) and occludin, in the intestinal tissues were significantly reduced after the induction of AP. However, oxymatrine increased the expression of claudin-1 and CD45, but did not alter the expression of ZO-1 and occludin. In conclusion, our results demonstrated that oxymatrine is potentially capably of protecting against l-arginine-induced AP and attenuating AP-associated intestinal barrier injury by up-regulation of claudin-1.
- Subjects
ARGININE; PANCREATITIS; LABORATORY rats; AMYLASES; LACTIC acid; TUMOR necrosis factors; LIPASES
- Publication
Inflammation, 2012, Vol 35, Issue 2, p605
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-011-9352-2