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- Title
Handgrip Strength Predicts Difficult Weaning But Not Extubation Failure in Mechanically Ventilated Subjects.
- Authors
Cottereau, Guillaume; Dres, Martin; Avenel, Alexandre; Fichet, Jérome; Jacobs, Frédéric M.; Prat, Dominique; Hamzaoui, Olfa; Richard, Christian; Antonello, Marc; Sztrymf, Benjamin
- Abstract
BACKGROUND: Muscle weakness, defined by the Medical Research Council scale, has been associated with delay in mechanical ventilation weaning. In this study, we evaluated handgrip strength as a prediction tool in weaning outcome. METHODS: This was a 1-y prospective study in 2 ICUs in 2 university hospitals. Adult patients who were on mechanical ventilation for at least 48 h and eligible for mechanical ventilation weaning were screened for inclusion. Handgrip strength was evaluated using a handheld dynamometer before each spontaneous breathing trial (SBT). Attending physicians were unaware of handgrip strength and decided on extubation according to guidelines. RESULTS: Eighty-four subjects were included (median age 66 [53-791 y, with a median Simplified Acute Physiology Score II of 49 [37-63]). At the first evaluation, median handgrip strength was significantly associated with weaning outcome as defined by international guidelines: simple (20 [12-26] kg), difficult (12 [6-21] kg), or prolonged (6 [3-11] kg) weaning (P = .008). Time to liberation from mechanical ventilation and ICU stay were significantly longer for subjects classified as having muscle weakness according to the handgrip strength-derived definition (P = .02 and P = .03, respectively). In multivariate analysis, known history of COPD (odds ratio [OR] 5.48, 95% Cl 1.44-20.86, P = .01), sex (OR 6.16, 95% Cl 1.64-23.16, P = .007), and handgrip strength at the first SBT (OR 0.89, 95% Cl 0.85-0.97, P = .004) were significantly associated with difficult or prolonged weaning. Extubation failure, as defined by re-intubation or unscheduled noninvasive ventilation within 48 h after extubation, occurred 14 times after 92 attempts, leading to an extubation failure rate of 15%. No association was found between handgrip strength and extubation outcome. CONCLUSIONS: Muscle weakness, assessed by handgrip strength, is associated with difficult or prolonged mechanical ventilation weaning and ICU stay, but not with extubation outcome.
- Subjects
FRANCE; ACADEMIC medical centers; ARTIFICIAL respiration; CHI-squared test; CONFIDENCE intervals; EXERCISE tests; FISHER exact test; GRIP strength; INTENSIVE care units; LONGITUDINAL method; OBSTRUCTIVE lung diseases; RESEARCH methodology; MULTIVARIATE analysis; MUSCLE contraction; MECHANICAL ventilators; TREATMENT effectiveness; CONTINUING education units; SEVERITY of illness index; EXTUBATION; DATA analysis software; MUSCLE weakness; DESCRIPTIVE statistics; ODDS ratio; MANN Whitney U Test; KRUSKAL-Wallis Test
- Publication
Respiratory Care, 2015, Vol 60, Issue 8, p1097
- ISSN
0020-1324
- Publication type
Article
- DOI
10.4187/respcare.03604