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- Title
Circulating Hsa-miR499a-5p as markers in dysmobility syndrome patients: a new index for diagnosing dysmobility syndrome based on osteoporosis and predicting fracture risk.
- Authors
Geng, Zixiang; Wang, Peige; Yang, Guangyue; Li, Yifei; Zhao, Yongfang
- Abstract
Background Dysmobility syndrome based on osteoporosis (ODS) is a disease characterized by low bone mass and low muscle mass. Its features are high fracture and high fall risk. Falls and fractures are the most important factors affecting the quality of life and lifespan of ODS. However, there is no serum marker for the evaluation of ODS patients. Our previous studies have shown that the expression of circulating miRNA is stable and is a good marker for disease diagnosis. Therefore, this study aims to explore potential serum markers of ODS. Methods A total of 78 subjects were included in this study. The data including appendicular skeletal muscle mass index, bone mineral density, bone metabolism markers, and other relevant information were collected for analysis. Real-time quantitative polymerase chain reaction was used to detect 19 miRNAs associated with muscle mass reduction. The correlation of quantitative data was analyzed by Pearson. The receiver operating characteristic curve was used to evaluate the performance of miRNA as a biomarker. Results In this study, we found that the muscle mass and strength of patients with ODS are significantly reduced and are negatively correlated with the risk of fracture. The hsa-miR-499a-5p is specifically downregulated in ODS, and is positively correlated with muscle mass and strength, and negatively correlated with the risk of fracture. Compared with muscle mass and strength, hsa-miR-499a-5p has better sensitivity and specificity as a diagnostic marker. Conclusion hsa-miR-499a-5p is a potential serum biomarker for assessing muscle function and predicting fall or fracture risk in the ODS population. Key message What is already known on this topic— Dysmobility syndrome based on osteoporosis (ODS) is a disease characterized by low bone mass and low muscle mass. ODS is a contributing factor to falls and fractures, but there is no serum marker for the evaluation of ODS patients. Our previous studies have shown that the expression of circulating miRNA is stable and is a good marker for disease diagnosis. What this study adds— hsa-miR-499a-5p is specifically downregulated in ODS, and is positively correlated with muscle mass and strength and negatively correlated with the risk of fracture. Compared with muscle mass and strength, hsa-miR-499a-5p has better sensitivity and specificity as a diagnostic marker. How this study might affect research, practice or policy— Serum hsa-miR-499a-5p can effectively evaluate muscle health impairment and the risk of falls and fractures. hsa-miR-499a-5p could contribute to the early diagnosis of ODS and the continuous monitoring and evaluation.
- Subjects
RECEIVER operating characteristic curves; BONE fractures; BONE density; GENE expression; MUSCLE mass; HIP fractures; BIOMARKERS
- Publication
Postgraduate Medical Journal, 2024, Vol 100, Issue 1183, p297
- ISSN
0032-5473
- Publication type
Article
- DOI
10.1093/postmj/qgae004