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- Title
Neuropsychological and neurophysiological findings in individuals suspected to be at risk for schizophrenia: preliminary results from the Basel early detection of psychosis study – Früherkennung von Psychosen (FEPSY).
- Authors
Gschwandtner, U.; Aston, J.; Borgwardt, S.; Drewe, M.; Feinendegen, C.; Lacher, D.; Lanzarone, A.; Stieglitz, R.‐D.; Riecher‐Rössler, A.
- Abstract
Objective: Our study aims to establish a scientific basis for the very early detection of patients at risk for schizophrenia during the nonspecific prodromal phase of the disorder and to predict its outbreak. Method: A multidomain approach is used. After screening, approved psychopathological, neurophysiological, neuropsychological and neuroradiological investigations are used to assess a sample of individuals suspected to be at risk for schizophrenia. Results: Neuropsychological and fine motor functioning tests as well as eye movement measurements showed statistically significant differences (P <0.01) between individuals suspected to be at risk for schizophrenia and healthy controls. Conclusion: Individuals suspected to be at risk for schizophrenia show specific impairments in various investigations including neuropsychological and fine motor functioning tests as well as eye movement measurements. A set of methods sensitive to even subtle changes in normal functioning may prove useful in predicting the subsequent outbreak of schizophrenia.
- Subjects
SCHIZOPHRENIA risk factors; NEUROPSYCHOLOGY; NEUROPHYSIOLOGY
- Publication
Acta Psychiatrica Scandinavica, 2003, Vol 108, Issue 2, p152
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1034/j.1600-0447.2003.00157.x