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- Title
Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis.
- Authors
Suda, Tsuyoshi; Takatori, Hajime; Hayashi, Takehiro; Kaji, Kiichiro; Nio, Kouki; Terashima, Takeshi; Shimakami, Tetsuro; Arai, Kuniaki; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Okumura, Kenichiro; Kozaka, Kazuto; Yamashita, Taro
- Abstract
Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death (p = 0.005), although the Child–Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (<54.0%) were associated with significantly worse prognosis than high levels in both overall survival (p = 0.0013) and survival excluding HCC-related death (p < 0.0001). Low plasma AT-III (<54.0%) was also associated with a significantly worse prognosis among patients with Child–Pugh A/B or ALBI grade 1/2 (p < 0.0001). Multivariate analyses indicated that low plasma AT-III levels (<54.0%) were an independent prognostic factor for poor survival outcome. Low plasma AT-III levels may be associated with mortality, particularly liver failure-related death, independent of liver function.
- Subjects
PATIENT portals; ANTITHROMBIN III; PORTAL vein; PROGNOSIS; SORAFENIB; ATAZANAVIR; CIRRHOSIS of the liver
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 9, p7732
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24097732