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- Title
Morin, a Flavonoid from Moraceae, Induces Apoptosis by Induction of BAD Protein in Human Leukemic Cells.
- Authors
Cheol Park; Won Sup Lee; Se-Il Go; Arulkumar Nagappan; Min Ho Han; Su Hyun Hong; Gon Sup Kim; Gi Young Kim; Taeg Kyu Kwon; Chung Ho Ryu; Sung Chul Shin; Yung Hyun Choi
- Abstract
Evidence suggests that phytochemicals can safely modulate cancer cell biology and induce apoptosis. Here, we investigated the anti-cancer activity of morin, a flavone originally isolated from members of the Moraceae family in human leukemic cells, focusing on apoptosis. An anti-cancer effect of morin was screened with several human leukemic cell lines. U937 cells were most sensitive to morin, where it induced caspase-dependent apoptosis in a dose-dependent manner. It also induced loss of MMP (??m) along with cytochrome c release, down-regulated Bcl-2 protein, and up-regulated BAX proteins. The apoptotic activity of morin was significantly attenuated by Bcl-2 augmentation. In conclusion, morin induced caspase-dependent apoptosis through an intrinsic pathway by upregulating BAD proteins. In addition, Bcl-2 protein expression is also important in morin-induced apoptosis of U937 cells. This study provides evidence that morin might have anticancer properties in human leukemic cells.
- Subjects
PHYSIOLOGICAL effects of flavonoids; APOPTOSIS inducing factor; BAX protein; MORIN; ANTINEOPLASTIC agents; MORACEAE; PROTEIN expression
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 1, p645
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms16010645