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- Title
Clinical Significance of POU5F1P1 rs10505477 Polymorphism in Chinese Gastric Cancer Patients Receving Cisplatin-Based Chemotherapy after Surgical Resection.
- Authors
Lili Shen; Mulong Du; Chun Wang; Dongying Gu; Meilin Wang; Qi Zhang; Tingting Zhao; Xunlei Zhang; Yongfei Tan; Xinying Huo; Weida Gong; Zhi Xu; Jinfei Chen; Zhengdong Zhang
- Abstract
This study aimed to investigate the association between POU class5 homeobox 1 pseudogene 1 gene (POU5F1P1) rs10505477 polymorphism and the prognosis of Chinese gastric cancer patients, who received cisplatin-based chemotherapy after surgical resection. POU5F1P1 rs10505477 was genotyped using the SNaPshot method in 944 gastric cancer patients who received gastrectomy. The association of rs10505477 G > A polymorphism with the progression and prognosis in gastric cancer patients was statistically analyzed using the SPSS version 18.0 for Windows. The results reveal that rs10505477 polymorphism has a negatively effect on the overall survival of gastric cancer patients in cisplatin-based chemotherapy subgroup (HR = 1.764, 95% CI = 1.069-2.911, p = 0.023). Our preliminary study indicates for the first time that POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy. Further studies are warranted to investigate the mechanism and to verify our results in different populations.
- Subjects
GENETIC polymorphisms; PSEUDOGENES; GASTRIC mucosa; CISPLATIN; CANCER chemotherapy; SURGICAL excision; CANCER
- Publication
International Journal of Molecular Sciences, 2014, Vol 15, Issue 7, p12764
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms150712764