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- Title
Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life.
- Authors
Paghera, S.; Quiros-Roldan, E.; Sottini, A.; Properzi, M.; Castelli, F.; Imberti, L.
- Abstract
Background: While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults, no data about these parameters are available in perinatally-infected patients with very long-lasting HIV infection. Methods: We compared thymic and bone marrow output, telomere length (measured by Real-Time PCR) and T-cell receptor repertoire (determined by spectratyping) of 21 perinatally HIV-infected subjects (with a median of 27 years of infection) with those of 19 age-matched non-perinatally HIV-infected patients and 40 healthy controls. All patients received a combined antiretroviral therapy. Results: While thymic and bone marrow output were not different among the analyzed groups, telomere length in peripheral blood cells and T-cell receptor diversity were significantly lower in HIV-perinatally and non-perinatally infected individuals compared to healthy controls. Conclusions: In HIV-infected subjects, a normal thymic output together with a reduced telomere length and a restricted T-cell receptor repertoire could be explained by the shift of newly produced cells into memory subsets. This phenomenon may allow to control viral infection and maintain peripheral homeostasis.
- Subjects
HOMEOSTASIS; HIV infections; LYMPHOCYTES; BLOOD cells; BONE marrow; DYSTHYMIC disorder; MEMORY
- Publication
Immunity & Ageing, 2019, Vol 16, Issue 1, pN.PAG
- ISSN
1742-4933
- Publication type
Article
- DOI
10.1186/s12979-019-0166-7