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- Title
An Efficient Route to Ethyl 5-Alkyl- (Aryl)-1 H-1,2,4-triazole-3-carboxylates.
- Authors
Chudinov, M. V.; Matveev, A. V.; Zhurilo, N. I.; Prutkov, A. N.; Shvets, V. I.
- Abstract
An efficient general route to the synthesis of 5-substituted 1 H-1,2,4-triazole-3-carboxylates was developed. N-acylamidrazones were obtained from carboxylic acid hydrazides and ethyl thiooxamate or ethyl 2-ethoxy-2-iminoacetate hydrochloride and then were reacted with chloroanhydride of the same carboxylic acid. As the next step, diacylamidrazones were cyclized to 5-substituted 1 H-1,2,4-triazole-3-carboxylates one pot in mild conditions.
- Subjects
CARBOXYLATES; ETHYL chloride; TRIAZOLES; HYDRAZIDES; CHEMICAL reactions
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 5, p1273
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.1934