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- Title
Drug-induced immune-mediated thrombocytopenia.
- Authors
Singh, Harpreet; Dhibar, Deba; Chaudhary, Deepak
- Abstract
A diagnosis of ATT-induced immune-mediated thrombocytopenia was made, and all the four anti-tubercular drugs (HRZE) were restarted in full dose and the dose of steroid was gradually tapered and subsequently stopped. Thrombocytopenia has been reported with all the first-line ATT drugs, mainly isoniazid, rifampicin, pyrazinamide, and ethambutol. George et al. proposed criteria for DIT for defining association between drug and thrombocytopenia.[[4]] Four criteria are: (i) the suspected drug must precede thrombocytopenia with complete and sustained recovery of the thrombocytopenia after withdrawal of the suspected drug, (ii) the suspected drug should be the only drug used prior to the onset of thrombocytopenia and/or other drugs are continued or reintroduced after discontinuing the suspected drug with a persistent normal platelet count, (iii) possible alternative etiologies for the thrombocytopenia are excluded, and (iv) recurrence of thrombocytopenia after reintroduction to the suspected drug.
- Subjects
THROMBOCYTOPENIA; DRUG side effects; HIV; PLATELET count; ERYTHROCYTES
- Publication
Indian Journal of Pharmacology, 2020, Vol 52, Issue 5, p439
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/ijp.IJP_365_20