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- Title
(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of NH Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines.
- Authors
Zhang, Shang ‐ Shi; Liu, Xu ‐ Ge; Chen, Shi ‐ Yong; Tan, Dong ‐ Hang; Jiang, Chun ‐ Yong; Wu, Jia ‐ Qiang; Li, Qingjiang; Wang, Honggen
- Abstract
A synthetic method for isoquinoline synthesis via a [4+2] annulation of NH imines with alkynes using the high-valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed.
- Subjects
ISOQUINOLINE synthesis; COBALT catalysts; IMINES; ALKYNES; CERIUM compounds; COPPER salts; SILVER salts
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 10, p1705
- ISSN
1615-4150
- Publication type
Other
- DOI
10.1002/adsc.201600025