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- Title
Cover Picture: Multi-Enzymatic Synthesis of Optically Pure β-Hydroxy α-Amino Acids (Adv. Synth. Catal. 4/2015).
- Authors
Hibi, Makoto; Kasahara, Takuya; Kawashima, Takashi; Yajima, Hiroko; Kozono, Shoko; Smirnov, Sergey V.; Kodera, Tomohiro; Sugiyama, Masakazu; Shimizu, Sakayu; Yokozeki, Kenzo; Ogawa, Jun
- Abstract
The front cover picture, provided by Makoto Hibi, Jun Ogawa et al., depicts Fe(II)/α ‐ ketoglutarate (αKG) ‐ dependent dioxygenases, which are hydroxylation biocatalysts catalyzing highly selective monooxygenation available to industrial applications. Recently, a great number of Fe(II)/αKG ‐ dependent dioxygenases with a variety of functions has been found in the genome database, and collected into a biocatalyst library. One of these enzymes, N ‐ succinyl L ‐ amino acid β ‐ hydroxylase, was applied to an enzymatic cascade system together with N ‐ succinyl L ‐ amino acid desuccinylase for the production of optically pure β ‐ hydroxy α ‐ amino acids. Details can be found in the full paper on pages 767 – 774 (M. Hibi, T. Kasahara, T. Kawashima, H. Yajima, S. Kozono, S. V. Smirnov, T. Kodera, M. Sugiyama, S. Shimizu, K. Yokozeki, and J. Ogawa, Adv. Synth. Catal. 2015, 357, 767 – 774; DOI: 10.1002/adsc.201400672).
- Subjects
CHEMICAL synthesis; CATALYSIS
- Publication
Advanced Synthesis & Catalysis, 2015, Vol 357, Issue 4, p605
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201500107