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- Title
Deracemization of Amino Acids by Coupling Transaminases of Opposite Stereoselectivity.
- Authors
Park, Eul ‐ Soo; Shin, Jong ‐ Shik
- Abstract
Biocatalytic deracemization of amino acids without relying on oxidase-based deamination of an unwanted enantiomer was demonstrated by coupling α- and ω-transaminases displaying opposite stereoselectivity. This strategy employs isopropylamine and a keto acid as cosubstrates and is free of generation of hydrogen peroxide which is troublesome in the conventional oxidase-based methods.
- Subjects
DERACEMIZATION; AMINO acid synthesis; AMINOTRANSFERASES; STEREOSELECTIVE reactions; BIOCATALYSIS
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 17, p3505
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201400185