We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of grinding on the dehydration behavior of nedocromil sodium hydrates.
- Authors
Hoshi, H.; Yonemochi, E.; Takagi, M.; Yoshihashi, Y.; Terada, K.
- Abstract
Nedocromil sodium has a number of known hydrate states, a monohydrate, a trihydrate and a heptahemihydrate, including an amorphous state. Effect of grinding on the hydration states of nedocromil sodium crystals was studied. After grinding the trihydrate, heptahemihydrate was observed in the ground sample, even though, the water content in the ground sample was not sufficient to cover the heptahemihydrate’s hydration level. On the other hand, in the ground heptahemihydrate, trihydrate was existed. Apparent activation energies (Δ E) for hydrates, monohydrate→anhydrate, trihydrate→monohydrate and heptahemihydrate→amorphous(anhydrate), were calculated using TG data. ΔE for the dehydration of heptahemihydrate was significantly lower than that of other hydrates. Obtained ΔE data explained the inter-conversion behavior of nedocromil sodium induced by grinding.
- Subjects
AMORPHOUS semiconductors; HYDRATION; GRINDING &; polishing; CRYSTALLOGRAPHY; THERMAL analysis; SCIENTIFIC experimentation
- Publication
Journal of Thermal Analysis & Calorimetry, 2008, Vol 92, Issue 2, p471
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-007-8973-z