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- Title
Pharmaceutical performance of solid dispersions containing poly(ethylene glycol) 6000 and diazepam or temazepam.
- Authors
Verheyen, S.; Blaton, N.; Kinget, R.; Van den Mooter, G.
- Abstract
Differential scanning calorimetry (DSC) data showed that the crystallinity of poly(ethylene glycol) 6000 in solid dispersions containing and diazeparn or temazepam only slightly increased upon aging and that the twice folded modification of the polymer unfolded into the once folded modification during aging, while the once folded modification did not unfold. This unfolding was found to be time and temperature dependent. X-ray powder diffraction data revealed that the drug crystallinity in the solid dispersions slightly increased upon aging. The dissolution profiles of aged and non-aged solid dispersions were comparable. It was concluded that polymer unfolding did not have an impact on the pharmaceutical performance of the investigated dispersions.
- Subjects
POLYETHYLENE glycol; DIAZEPAM; POLYMERS; THERMAL analysis; CALORIMETRY
- Publication
Journal of Thermal Analysis & Calorimetry, 2004, Vol 76, Issue 2, p405
- ISSN
1388-6150
- Publication type
Article