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- Title
Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro.
- Authors
Li, Junyang; Tang, Chao; Li, Liwen; Li, Rujun; Fan, Youwu
- Abstract
We previously demonstrated that the acquired resistance because of Hsp27 activation weakens the cytotoxic effect of t-AUCB on glioblastoma cells. Since autophagy is regarded as a survival mechanism for cells exposed to cytotoxic agents, the aim of this study is to investigate whether t-AUCB induces autophagy and whether Hsp27 and autophagy are interacted with each other. Our data demonstrated that t-AUCB induces autophagy in glioblastoma cells and regulates multiple autophagy related-gene expression. t-AUCB induces overexpression of Atg7, which is downstream of Hsp27 and participates in the resistance of glioblastoma cells to t-AUCB treatment. Hsp27 inhibitor quercetin suppresses Atg7 expression and strengthens t-AUCB-induced cell death by autophagy blockage. We concluded that combination of quercetin and t-AUCB might be a potential strategy for glioblastoma treatment.
- Subjects
GLIOBLASTOMA multiforme; QUERCETIN; AUTOPHAGY; HEAT shock proteins; GENETIC regulation; CELL-mediated cytotoxicity; IN vitro studies; THERAPEUTICS
- Publication
Journal of Neuro-Oncology, 2016, Vol 129, Issue 1, p39
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-016-2149-2