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- Title
Natural HLA class I ligands from glioblastoma: extending the options for immunotherapy.
- Authors
Neidert, Marian; Schoor, Oliver; Trautwein, Claudia; Trautwein, Nico; Christ, Lisa; Melms, Arthur; Honegger, Jürgen; Rammensee, Hans-Georg; Herold-Mende, Christel; Dietrich, Pierre-Yves; Stevanović, Stefan
- Abstract
Glioblastoma multiforme is the most frequent and most malignant primary brain tumor with poor prognosis despite surgical removal and radio-chemotherapy. In this setting, immunotherapeutical strategies have great potential, but the reported repertoire of tumor associated antigens is only for HLA-A*02 positive tumors. We describe the first analysis of HLA-peptide presentation patterns in HLA-A*02 negative glioma tissue combined with gene expression profiling of the tumor samples by oligonucleotide microarrays. We identified numerous candidate peptides for immunotherapy. These are peptides derived from proteins with a well-described role in glioma tumor biology and suitable gene expression profiles such as PTPRZ1, EGFR, SEC61G and TNC. Information obtained from complementary analyses of HLA-A*02 negative tumors not only contributes to the discovery of novel shared glioma antigens, but most importantly provides the opportunity to tailor a patient-individual cocktail of tumor-associated peptides for a personalized, targeted immunotherapeutic approach in HLA-A*02 negative patients.
- Subjects
HLA histocompatibility antigens; IMMUNOTHERAPY; GLIOMAS; GLIOBLASTOMA multiforme; LIGANDS (Biochemistry); OLIGONUCLEOTIDE arrays; GENE expression profiling
- Publication
Journal of Neuro-Oncology, 2013, Vol 111, Issue 3, p285
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-012-1028-8