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- Title
Comparison of three S-β-CDs with different degrees of substitution for the chiral separation of 12 drugs in capillary electrophoresis.
- Authors
Wang, Zhaokun; Zhang, Qiongwen; Luo, Linda; Sun, Tiemin; Guo, Xingjie
- Abstract
Three kinds of sulfated β-cyclodextrin (S-β-CD), including a single isomer, heptakis-6-sulfato-β-cyclodextrin (HS-β-CD), degree of substitution (DS) of 7, which was synthesized in our laboratory and another two commercialized randomly substituted mixtures, a sulfated β-cyclodextrin with DS of 7 to 11, as well as a highly sulfated-β-cyclodextrin with DS of 12 to 15, were used for the enantioresolution of 12 drugs (the β-blockers, phenethylamines, and anticholinergic agents) in capillary electrophoresis. The enantioseparation under varying concentrations of S-β-CD and background electrolyte pH were systematically investigated and compared. Based on the experimental results, the effect of the nature of S-β-CD and analyte structure on the enantioseparation is discussed.
- Subjects
DRUG analysis; SUBSTITUTION reactions; CHIRALITY; SEPARATION (Technology); ELECTROPHORESIS; MOLECULAR structure
- Publication
Chirality, 2017, Vol 29, Issue 9, p558
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22731