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- Title
Rapid T<sub>1</sub> mapping of mouse myocardium with saturation recovery look-locker method.
- Authors
Li, Wen; Griswold, Mark; Yu, Xin
- Abstract
Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T1 mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo-planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice ( n = 6). Our results showed a strong agreement between T1 measured by saturation recovery Look-Locker and by the standard saturation recovery method in vitro or inversion recovery Look-Locker in vivo. The utility of saturation recovery Look-Locker in dynamic contrast-enhanced MRI studies was demonstrated in manganese-enhanced MRI experiments in mice. Our results suggest that saturation recovery Look-Locker can provide rapid and accurate cardiac T1 mapping for studies using small animal models. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2010, Vol 64, Issue 5, p1296
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.22544