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- Title
Osteoporosis and the Risk of Symptomatic Nephrolithiasis: A Population-Based 5-Year Follow-Up Study in Taiwan.
- Authors
Chou, Ping-Song; Kuo, Chun-Nan; Hung, Kuo-Sheng; Chang, Wei-Chiao; Liao, Yu-Chien; Chi, Ying-Chen; Chou, Wei-Po; Tsai, Shih-Jen; Liu, Mu-En; Lai, Chiou-Lian; Chou, Yii-Her; Chang, Wei-Pin
- Abstract
This study estimates the risk of symptomatic nephrolithiasis within 5 years of newly diagnosed osteoporosis in a Taiwan population. This cohort study consisted of patients with a diagnosis of osteoporosis between Jan. 2003 and Dec. 2005 ( N = 1634). Four age- and gender- matched patients for every patient in the study cohort were selected using random sampling as the comparison cohort ( N = 6536). All patients were tracked for 5 years from the date of cohort entry to identify whether they developed symptomatic nephrolithiasis. Cox proportional hazard regressions were performed to evaluate the 5-year nephrolithiasis-free survival rates. During the 5-year follow-up period, 60 osteoporosis patients (3.7 %) and 165 non- osteoporosis patients (2.5 %) developed symptomatic nephrolithiasis. The adjusted HR of symptomatic nephrolithiasis was 1.38 times greater risk for patients with osteoporosis than for the comparison cohort (95% confidence interval (CI) 1.03-1.86; P < .05). Osteoporosis is very likely to be an independent risk factor for subsequent diagnosis of symptomatic nephrolithiasis.
- Subjects
TAIWAN; OSTEOPOROSIS diagnosis; OSTEOPOROSIS; KIDNEY stone risk factors; FOLLOW-up studies (Medicine); COHORT analysis; PROPORTIONAL hazards models; PATIENTS
- Publication
Calcified Tissue International, 2014, Vol 95, Issue 4, p317
- ISSN
0171-967X
- Publication type
Article
- DOI
10.1007/s00223-014-9895-y