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- Title
High levels of diversity characterize mandrill ( Mandrillus sphinx) Mhc-DRB sequences.
- Authors
Abbott, Kristin M.; Wickings, E. Jean; Knapp, Leslie A.
- Abstract
The major histocompatibility complex (MHC) is highly polymorphic in most primate species studied thus far. The rhesus macaque ( Macaca mulatta) has been studied extensively and the Mhc-DRB region demonstrates variability similar to humans. The extent of MHC diversity is relatively unknown for other Old World monkeys (OWM), especially among genera other than Macaca. A molecular survey of the Mhc-DRB region in mandrills ( Mandrillus sphinx) revealed extensive variability, suggesting that other OWMs may also possess high levels of Mhc-DRB polymorphism. In the present study, 33 Mhc-DRB loci were identified from only 13 animals. Eleven were wild-born and presumed to be unrelated and two were captive-born twins. Two to seven different sequences were identified for each individual, suggesting that some mandrills may have as many as four Mhc-DRB loci on a single haplotype. From these sequences, representatives of at least six Mhc-DRB loci or lineages were identified. As observed in other primates, some new lineages may have arisen through the process of gene conversion. These findings indicate that mandrills have Mhc-DRB diversity not unlike rhesus macaques and humans.
- Subjects
MAJOR histocompatibility complex; IMMUNOGENETICS; PRIMATES; SPECIES; RHESUS monkeys; GENETIC polymorphisms
- Publication
Immunogenetics, 2006, Vol 58, Issue 8, p628
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s00251-006-0132-3