We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Intravitreal bevacizumab treatment for neovascular glaucoma: histopathological analysis of trabeculectomy specimens.
- Authors
Yoshida, Noriko; Hisatomi, Toshio; Ikeda, Yasuhiro; Kohno, Ri-ichiro; Murakami, Yusuke; Imaki, Hiroyuki; Ueno, Akifumi; Fujisawa, Kimihiko; Ishibashi, Tatsuro
- Abstract
Background: Neovascular glaucoma (NVG) is a serious complication for patients with proliferative diabetic retinopathy (PDR). Bevacizumab is a full-length humanized monoclonal antibody that binds all isoforms of vascular endothelial growth factor (VEGF). Recently, encouraging results regarding the off-label use of intravitreal bevacizumab (IVB) for the treatment of NVG have been reported. We evaluated the histology of bevacizumab-treated trabeculectomy specimens to clarify IVB's biological effects on angle neovascularization. Methods: We retrospectively reviewed the charts of a consecutive series of 15 eyes of 13 patients who underwent trabeculectomy to treat NVG caused by PDR. In ten eyes of eight patients, 1.25 mg bevacizumab was injected intravitreally via the pars plana. Using light or electron microscopy, the surgically excised trabecular tissue was compared to that without IVB. Results: Light microscopy revealed decreased edema, fibrin deposition, inflammation and vascular congestion in the trabecular meshwork in specimens with IVB compared to those without IVB. Electron microscopy revealed endothelial cell degeneration in the bevacizumab-treated specimens. Conclusions: The biological effects on angle neovascularization after IVB may involve reduced vascular permeability, decreased inflammatory reaction, loss of vascular function, and endothelial cell degeneration.
- Subjects
GLAUCOMA surgery; BEVACIZUMAB; MONOCLONAL antibodies; DIABETIC retinopathy; NEOVASCULARIZATION; VASCULAR endothelial growth factors; ELECTRON microscopy
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2011, Vol 249, Issue 10, p1547
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-011-1761-2