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- Title
Production of metabolites with antioxidant activity by Botryosphaeria dothidea in submerged fermentation.
- Authors
Druzian, Susanne Pedroso; Pinheiro, Luíza Negri; Susin, Nathália Marques Bastos; Dal Prá, Valéria; Mazutti, Marcio Antonio; Kuhn, Raquel Cristine; Terra, Lisiane de Marsillac
- Abstract
Antioxidants are able of inhibiting free radicals and play an important role in human diet, protection of foods, anti-aging cosmetics, among others. Fungi have been highlighted in production of metabolites with biological activity, such as antioxidant. The main objective of this study was to select a fungus from resources of Brazilians Pampa and Atlantic Forest biomes with hability for production of antioxidants by submerged fermentation. The scavenging activity of the compounds was determined against radical 2.2-diphenyl-1-picrylhydrazyl (DPPH), superoxide and hydroxyl. Botryosphaeria dothidea exhibited higher potential for the production of antioxidants, and its supernatant showed percentage inhibition values of 94.47, 94.87 and 89.78% against DPPH, superoxide and hydroxyl radicals and IC50 of 0.206 mg/mL. The identification of the volatile compounds present in the broth verified the presence of the hexahydropyrrolizin-3-one; 1.2-benzenedicarboxylic acid bis(2-methylpropyl) ester and 3.6-bis(2-methylpropyl)-2.5-piperazinedione. According to this study, Botryosphaeria dothidea presents great potential to produce compounds with antioxidant activity.
- Subjects
PAMPAS (Argentina); FERMENTATION; HYDROXYL group; FREE radicals; ANTIOXIDANTS; ENDOPHYTIC fungi; SUPEROXIDES
- Publication
Bioprocess & Biosystems Engineering, 2020, Vol 43, Issue 1, p13
- ISSN
1615-7591
- Publication type
Article
- DOI
10.1007/s00449-019-02200-y