We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
PLAG1 fusions extend the spectrum of PLAG(L)-altered CNS tumors.
- Authors
Tauziède-Espariat, Arnault; Siegfried, Aurore; Nicaise, Yvan; Dghayem, Delphine; Laprie, Anne; Lubrano, Vincent; Richard, Pomone; Gauchotte, Guillaume; Malczuk, Joséphine; Klein, Olivier; Hasty, Lauren; Métais, Alice; Chrétien, Fabrice; Dangouloff-Ros, Volodia; Boddaert, Nathalie; Sahm, Felix; Sievers, Philipp; Varlet, Pascale; Uro-Coste, Emmanuelle
- Abstract
To conclude, we report, for the first time, two embryonal tumors with I PLAG1 i fusions sharing clinico-radiological, histopathological, immunohistochemical, and epigenetic similarities to CNS embryonal tumors with PLAG-family amplification. Central Nervous System (CNS) embryonal tumors with PLAG-family amplification have been isolated by a distinct DNA-methylation profile [[1]]. References 1 Keck M-K, Sill M, Wittmann A, Joshi P, Stichel D, Beck P. Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.
- Subjects
SALIVARY glands; GENE amplification; CENTRAL nervous system tumors; TUMORS
- Publication
Acta Neuropathologica, 2023, Vol 146, Issue 6, p841
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-023-02643-4