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- Title
Clinical Effects of Oseltamivir, Zanamivir, Laninamivir and Peramivir on Seasonal Influenza Infection in Outpatients in Japan during the Winter of 2012-2013.
- Authors
Takemoto, Yuji; asai, Teizaburo; Ikezoe, Itsuo; Yano, Takako; Ichikawa, Masahiro; Miyagawa, Shogo; Matsumoto, Jun
- Abstract
Background: The neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, laninamivir and peramivir are available in Japan. However, the selective use of NAIs for treating outpatients with influenza has not been clearly defined. Methods: We assigned 191 patients with influenza to 4 groups, each treated with a different NAI, and then compared how long it took to alleviate fever and other symptoms and to eliminate the virus. Results: Alleviation of fever occurred significantly sooner with peramivir than with either zanamivir (p = 0.0002) or oseltamivir (p = 0.0059), but was not significantly different from that with laninamivir (p = 0.0457; p < 0.0083). Other symptoms were also alleviated sooner by peramivir than by the other 3 NAIs. Conclusions: The ability of each NAI to alleviate influenza symptoms and fever varied. The appropriate use of NAIs requires further study. © 2014 S. Karger AG, Basel
- Subjects
JAPAN; OSELTAMIVIR; RELENZA (Drug); SEASONAL influenza; OUTPATIENT medical care; NEURAMINIDASE; ENZYME inhibitors; THERAPEUTICS
- Publication
Chemotherapy (0009-3157), 2014, Vol 59, Issue 5, p373
- ISSN
0009-3157
- Publication type
Article
- DOI
10.1159/000362436