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- Title
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
- Authors
Maser, Richard S.; Choudhury, Bhudipa; Campbell, Peter J.; Bin Feng; Kwok-Kin Wong; Protopopov, Alexei; O’Neil, Jennifer; Gutierrez, Alejandro; Ivanova, Elena; Perna, Ilana; Lin, Eric; Mani, Vidya; Shan Jiang; McNamara, Kate; Zaghlul, Sara; Edkins, Sarah; Stevens, Claire; Brennan, Cameron; Martin, Eric S.; Wiedemeyer, Ruprecht
- Abstract
Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome.
- Subjects
CANCER genes; CANCER genetics; GENOMICS; MOLECULAR genetics; LYMPHOMAS; TUMOR genetics
- Publication
Nature, 2007, Vol 447, Issue 7147, p966
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature05886