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- Title
Differential immune responses in pregnant patients recovered from COVID-19.
- Authors
Chen, Ge; Zhang, Yiming; Zhang, Yaoyao; Ai, Jihui; Yang, Bin; Cui, Mengge; Liao, Qiuyue; Chen, Hanxiao; Bai, Hualin; Shang, Dashing; Chen, Jing; Sun, ChaoYang; Liu, Haiyi; Liu, Fengyuan; Mao, Bin; Sun, Guoqiang; Chen, Lu; Lin, Jing-wen; Li, Kezhen
- Abstract
Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 in pregnancy remains to be determined, evidence indicates that the risk factors for severe COVID-19 are similar in pregnancy to the general population. Here we systemically analyzed the clinical characteristics of pregnant and non-pregnant female COVID-19 patients who were hospitalized during the same period and found that pregnant patients developed marked lymphopenia and higher inflammation evident by higher C-reactive protein and IL-6. To elucidate the pathways that might contribute to immunopathology or protective immunity against COVID-19 during pregnancy, we applied single-cell mRNA sequencing to profile peripheral blood mononuclear cells from four pregnant and six non-pregnant female patients after recovery along with four pregnant and three non-pregnant healthy donors. We found normal clonal expansion of T cells in the pregnant patients, heightened activation and chemotaxis in NK, NKT, and MAIT cells, and differential interferon responses in the monocyte compartment. Our data present a unique feature in both innate and adaptive immune responses in pregnant patients recovered from COVID-19.
- Publication
Signal Transduction & Targeted Therapy, 2021, Vol 6, Issue 1, p1
- ISSN
2095-9907
- Publication type
Article
- DOI
10.1038/s41392-021-00703-3