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- Title
Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment.
- Authors
Xu, He; Yuan, Xu-Dong; Shen, Bao-De; Han, Jin; Lv, Qing-Yuan; Dai, Ling; Lin, Ming-Gui; Yu, Chao; Bai, Jin-Xia; Yuan, Hai-Long
- Abstract
In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the hydrogel-grafted fabrics to achieve sustained drug release. The prepared hydrogel-grafted fabrics embedding of berberine nanosuspension was characterized by FT-IR spectroscopy, scanning electron microscopy, and swelling degree studies. Fourier transform infrared spectroscopy revealed that berberine was embedded into the matrix of hydrogel-grafted fabrics, rather than on the surface. Scanning electron microscopy showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that hydrogel-grafted fabric had water absorbing characteristic with reversible temperature sensitivity. The drug release study demonstrated that hydrogel-grafted fabrics can be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded hydrogel-grafted fabric was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.
- Subjects
ACRYLAMIDE; ALGINATES; GRAFT copolymers; HYDROGELS; BERBERINE; WOUND care; AMMONIUM nitrate; THERAPEUTICS
- Publication
Journal of Biomaterials Applications, 2014, Vol 28, Issue 9, p1376
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328213509503