We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Enhanced Regeneration of Critical Bone Defects Using a Biodegradable Gelatin Sponge and b-Tricalcium Phosphate with Bone Morphogenetic Protein-2.
- Authors
MATSUMOTO, GOICHI; OMI, YASUSHI; KUBOTA, EIRO; OZONO, SATORU; TSUZUKI, HIDEKO; KINOSHITA, YUKIHIKO; YAMAMOTO, MASAYA; TABATA, YASUHIKO
- Abstract
We examine the osteogenicity of a sponge biomaterial consisting of a biodegradable mixture of gelatin and b-tricalcium phosphate (βTCP) that bound bone morphogenetic protein 2 (BMP-2) in critical-sized bone defects in rats. Gelatin-&ebta;TCP sponges containing either phosphate buffered saline or incorporating BMP-2 are implanted into 5mm diameter bone defects created in rat mandibles. We assess the defects biweekly for 8 weeks following implantation. There is significantly higher osteoinductive activity and significantly more Gla-osteocalcin content at bone-defect healing sites treated with gelatin-βTCP sponges incorporating BMP-2 than there is in those treated with sponges that did not contain BMP-2. Histologically, new bone that contains bone marrow and that is connected to the original bone almost entirely replaces the regenerated bone. These results show that biodegradable gelatin-βTCP incorporating BMP-2 is osteogenic enough to promote healing in large bone defects.
- Subjects
BONE regeneration; BONE diseases; BONE morphogenetic proteins; BIOMEDICAL materials; PHOSPHATES; BONE marrow
- Publication
Journal of Biomaterials Applications, 2009, Vol 24, Issue 4, p327
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328208096523