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- Title
Viral Vectors in Gene Therapy.
- Authors
Lundstrom, Kenneth
- Abstract
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed for the treatment of various diseases such as metabolic, cardiovascular, muscular, hematologic, ophthalmologic, and infectious diseases and different types of cancer. Recent development in the area of immunotherapy has provided both preventive and therapeutic approaches. Furthermore, gene silencing generating a reversible effect has become an interesting alternative, and is well-suited for delivery by viral vectors. A number of preclinical studies have demonstrated therapeutic and prophylactic efficacy in animal models and furthermore in clinical trials. Several viral vector-based drugs have also been globally approved.
- Subjects
VECTOR analysis; VIRAL genomes; GENE therapy; IMMUNOTHERAPY; GENE silencing; CLINICAL trials
- Publication
Diseases, 2018, Vol 6, Issue 2, p42
- ISSN
2079-9721
- Publication type
Article
- DOI
10.3390/diseases6020042