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- Title
Ice, ice, maybe? Is it time to ditch the igloo cooler? Benefits of machine perfusion preservation of donor hearts.
- Authors
Vela, Ryan J.; Jessen, Michael E.; Peltz, Matthias
- Abstract
The ability to affect donor organ physiology is extensive, not only by adjustments of perfusion parameters, but also infusion of inotropes, substrates, or hormonal manipulation, for example.[48] Donor organ evaluation during perfusion may even include echocardiography or cardiac catheterization.[[49]] Device operation is more complex than for hypothermic perfusion preservation devices and usually requires additional team members than just the recovering surgeon. Truly remarkable results have been achieved by selected centers in Australia and the UK when OCS Heart is used for recovery DCDD donors, an otherwise unutilized donor pool for cardiac transplantation.[55] To date, over 100 transplants from DCDD donors have been performed. Current machine perfusion preservation technologies for donor hearts, either in use or under development, are promising for increasing the donor pool and recovery of otherwise unacceptable donors, but still operate under temporal constraints that limit optimal donor--recipient matching. Once overcome, long-term organ perfusion systems would revolutionize the field of cardiac transplantation and alleviate donor shortages not only by recovery and resuscitation of most donor hearts, but also use of bioengineered organs, and potentially xenotransplantation.
- Subjects
PERFUSION; MYOCARDIAL reperfusion; OXYGEN carriers; HEART transplantation; HEART; HLA histocompatibility antigens; ARTIFICIAL organs; ICE
- Publication
Artificial Organs, 2020, Vol 44, Issue 3, p220
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1111/aor.13599