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- Title
Association of fibrotic markers with diastolic function after STEMI.
- Authors
Al Ali, Lawien; Meijers, Wouter C.; Beldhuis, Iris E.; Groot, Hilde E.; Lipsic, Erik; van Veldhuisen, Dirk J.; Voors, Adriaan A.; van der Horst, Iwan C. C.; de Boer, Rudolf A.; van der Harst, Pim
- Abstract
Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in patients suffering an ST-elevated myocardial infarction (STEMI). We analyzed 236 patients from the GIPS-III cohort with available echocardiographic studies and plasma measurements at hospitalization and after 4 months follow-up. Adjusted logistic mixed effects modelling revealed no association between the occurrence of diastolic dysfunction over time with abnormal plasma levels of galectin-3 and ST2. We observed no differences regarding survival outcome at follow-up of 5 years between patients with normal versus abnormal values in both galectin-3 (P = 0.75), and ST2 (P = 0.85). In conclusion, galectin-3 and sST2 were not associated with the development of diastolic dysfunction in non-diabetic patients that presented with a STEMI.
- Subjects
ST elevation myocardial infarction; GALECTINS; HEART fibrosis; SURVIVAL rate; PROGNOSIS; DIASTOLE (Cardiac cycle)
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-69926-y