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- Title
New Pharmacological Developments in the Treatment of Hepatocellular Cancer.
- Authors
Gusani, Niraj J.; Yixing Jiang; Kimchi, Eric T.; Staveley-O'Carroll, Kevin F.; Hua Cheng; Ajani, Jaffer A.
- Abstract
Hepatocellular carcinoma (HCC) is the most common primary liver neoplasm and fourth leading cause of cancer death worldwide. The survival for patients with advanced HCC is extremely poor. This is largely attributed to the lack of effective screening methods, advanced stage at presentation, limited utility of surgical intervention and ineffective medical therapy. Over the past 30 years, many conventional cytotoxic agents have been tested and have failed to confer a survival benefit. Recently, sorafenib, a multi-tyrosine kinase inhibitor, was approved by the US FDA as first-line therapy in HCC as the first agent demonstrating survival benefit in this disease. Although the survival benefit demonstrated by sorafenib is moderate, molecular targeted therapy has brought new hope in the management of HCC.
- Subjects
LIVER cancer; THERAPEUTICS; ETIOLOGY of diseases; PHARMACOLOGY; MEDICAL screening; PROTEIN-tyrosine kinases
- Publication
Drugs, 2009, Vol 69, Issue 18, p2533
- ISSN
0012-6667
- Publication type
Article
- DOI
10.2165/11530870-000000000-00000