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- Title
Assessment of strain and strain rate by two-dimensional speckle tracking in mice: comparison with tissue Doppler echocardiography and conductance catheter measurements.
- Authors
Ferferieva, V.; Van den Bergh, A.; Claus, P.; Jasaityte, R.; La Gerche, A.; Rademakers, F.; Herijgers, P.; D'hooge, J.
- Abstract
Aims This study was designed in order to compare the strain and strain rate deformation parameters assessed by speckle tracking imaging (STI) with those of tissue Doppler imaging (TDI) and conductance catheter measurements in chronic murine models of left ventricular (LV) dysfunction. Methods and results Twenty-four male C57BL/6J mice were assigned to wild-type (n = 8), myocardial infarction (n = 8) and transaortic constriction (n = 8) groups. Echocardiographic and conductance measurements were simultaneously performed at rest and during dobutamine infusion (5 µg/kg/min) in all animals 10 weeks post-surgery. The LV circumferential strain (Scirc) and the strain rate (SRcirc) were derived from grey scale and tissue Doppler data at frame rates of 224 and 375 Hz, respectively. Scirc and SRcirc by TDI/STI correlated well with the preload recruitable stroke work (PRSW) (r = −0.64 and −0.71 for TDI; r = −0.46 and −0.50 for STI, P < 0.05). Both modalities showed a good agreement with respect to Scirc and SRcirc (r = 0.60 and r = 0.63, P < 0.05). During stress, however, TDI-estimated Scirc and SRcirc values were predominantly higher than those measured by STI (P < 0.05). The similarity of Scirc and SRcirc measurements with respect to the STI/TDI data was examined by the Bland–Altman analysis. Conclusion In mice, the STI- and TDI-derived strain and strain rate deformation parameters relate closely to intrinsic myocardial function. At low heart rate-to-frame rate ratios (HR/FR), both STI and TDI are equally acceptable for assessing the LV function non-invasively in these animals. At HR/FR (e.g. dobutamine challenge), however, these methods cannot be used interchangeably as STI underestimates S and SR at high values.
- Subjects
MYOCARDIAL infarction complications; ECHOCARDIOGRAPHY; HEART ventricle diseases; ANALYSIS of variance; ANIMAL experimentation; STATISTICAL correlation; LEFT heart ventricle; HEMODYNAMICS; MICE; RESEARCH funding; STATISTICS; T-test (Statistics); DATA analysis; DATA analysis software; DESCRIPTIVE statistics
- Publication
European Heart Journal - Cardiovascular Imaging, 2013, Vol 14, Issue 8, p765
- ISSN
2047-2404
- Publication type
Article
- DOI
10.1093/ehjci/jes274