We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Impact of Computed Tomography on oxidative stress.
- Authors
Yıldız, Sema; Çeçe, Hasan; Aktı, Zeynep; Kaya, İhsan; Çelik, Hakim; Çakır, Hale; Taşkın, Abdullah; Aksoy, Nurten
- Abstract
Methods: The study included 28 patients undergoing non contrast-enhanced cranial CT with spiral CT (Toshiba Xvision®, Tokyo, Japan). Venous blood samples were withdrawn at baseline (Group I), and after non contrast-enhanced CT (Group II). Serum ceruloplasmin levels were determined with an automatic colorimetric method, whereas serum LOOH levels were determined by the ferrous ion oxidation-xylenol orange (FOX-2) method based on a known principle of the oxidation of Fe II to Fe III by lipid hydroperoxides, under acidic conditions. The concentration of sulfhydryl groups was calculated spectrophotometrically using reduced glutathione as the free sulfhydryl group. Comparison of serum oxidative stress markers among two groups of samples from each case were performed with paired samples t-test. Results: Serum LOOH (4.71±1.43 vs. 5.13±1.53 µmol tBLOOH/L, respectively, p=0.179) and -SH levels (.311±.029 and .305±.025 mmol/L respectively, p=0.084) were not significantly different between Groups I and II. Serum ceruloplasmin was significantly decreased in Group II compared to Group I (741.7±70.7 vs.757.4±63.6 U/L respectively, p=0.015). Conclusions: Besides the previous studies revealing deleterious effects of CT, the present study has shown decreased serum ceruloplasmin levels [besides unchanged serum LOOH and -SH levels] after performing non contrast-enhanced CT compared to baseline that might reveal a novel untoward effect of CT which should be reinforced with further researches.
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2012, Vol 9, Issue 3, p99
- ISSN
1304-9623
- Publication type
Journal Article