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- Title
Association Analysis of 14 Candidate Gene Polymorphism with Depression and Stress among Gestational Diabetes Mellitus.
- Authors
Lee, Kai Wei; Ching, Siew Mooi; Ramachandran, Vasudevan; Tusimin, Maiza; Mohd Nordin, Noraihan; Chong, Seng Choi; Hoo, Fan Kee
- Abstract
The association of candidate genes and psychological symptoms of depression, anxiety, and stress among women with gestational diabetes mellitus (GDM) in Malaysia was determined in this study, followed by the determination of their odds of getting psychological symptoms, adjusted for socio-demographical background, maternal, and clinical characteristics. Single nucleotide polymorphisms (SNPs) recorded a significant association between SNP of EPHX2 (rs17466684) and depression symptoms (AOR = 7.854, 95% CI = 1.330–46.360) and stress symptoms (AOR = 7.664, 95% CI = 1.579–37.197). Associations were also observed between stress symptoms and SNP of OXTR (rs53576) and (AOR = 2.981, 95% CI = 1.058–8.402) and SNP of NRG1 (rs2919375) (AOR = 9.894, 95% CI = 1.159–84.427). The SNP of EPHX2 (rs17466684) gene polymorphism is associated with depression symptoms among Malaysian women with GDM. SNP of EPHX2 (rs17466684), OXTR (rs53576) and NRG1 (rs2919375) are also associated with stress symptoms.
- Subjects
MALAYSIA; GENETIC polymorphisms; SINGLE nucleotide polymorphisms; MENTAL depression; GESTATIONAL diabetes; ANXIETY in women; DIABETES in women
- Publication
Genes, 2019, Vol 10, Issue 12, p988
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes10120988