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- Title
Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants.
- Authors
Hongmei Nan; Hutter, Carolyn M.; Yi Lin; Jacobs, Eric J.; Ulrich, Cornelia M.; White, Emily; Baron, John A.; Berndt, Sonja I.; Brenner, Hermann; Butterbach, Katja; Caan, Bette J.; Campbell, Peter T.; Carlson, Christopher S.; Casey, Graham; Chang-Claude, Jenny; Chanock, Stephen J.; Cotterchio, Michelle; Duggan, David; Figueiredo, Jane C.; Fuchs, Charles S.
- Abstract
The article discusses research which examined gene-environment interactions between regular use of aspiring and/or nonteroidal anti-inflammatory drugs (NSAIDs) and single-nucleotide polymorphisms (SNPs) in relation to colorectal cancer risk. Topics covered include the association between regular use of aspirin/NSAIDs with lower risk cancer, the genome-wide significant interaction shown by the SNP rs2965667 with aspirin/NSAID use and the high cancer risk among those with rate TA or AA genotypes.
- Subjects
GENOTYPE-environment interaction; NONSTEROIDAL anti-inflammatory agents; SINGLE nucleotide polymorphisms; COLON cancer risk factors; GENOMES; GENOTYPES
- Publication
JAMA: Journal of the American Medical Association, 2015, Vol 313, Issue 11, p1133
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2015.1815