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- Title
Eficacia analgésica de la combinación de clonixinato de lisina y diclofenaco versus ibuprofeno o ketorolaco después de la extracción del tercer molar mandibular impactado. Estudio piloto.
- Authors
Pérez-Urizar, José; de Jesús Pozos-Guillén, Amaury; Martínez-Rider, Ricardo; Torres-Roque, Irma; Aguilera-Suárez, Graciela; Gómez-Sánchez, Miguel
- Abstract
Introduction: It is common in dental practice to use an analgesic-based drug treatment in order to reduce the pain in patients that have undergone surgical procedures. The aim of this study is to compare the analgesic and anti-inflammatory efficacy, trismus control, and tolerability of a lysine clonixinate + diclofenac mixture as opposed to ibuprofen or ketorolac following impacted third molar extraction. Material and methods: A double-blind, multiple-dose pilot study of parallel groups was carried out. Patients were randomized into three groups: Group A, ibuprofen, 600 mg orally; Group B: diclofenac, 250 mg + 50 mg orally, and Group C: ketorolac, 10 mg orally. Intensity of pain, pain relief, inflammation, trismus, and tolerability were evaluated. Results: At 24 and 72 hours, pain relief in the diclofenac group was greater compared with the ibuprofen group and greater than ketorolac at 72 hours. Sixty-six percent of the patients treated with ibuprofen at 48 hours following surgery and 16% of those treated with ketorolac at 72 hours required relief medication, whereas no patients in the diclofenac group did. Inflammation rates were lower in the diclofenac group. Trismus was similar among the groups. Conclusions: The analgesic efficacy of the diclofenac mixture is greater than that produced by the standard dose of ibuprofen and at least equal to that produced by ketorolac in the treatment of postoperative pain following impacted third molar extraction.
- Subjects
HEALTH outcome assessment; DICLOFENAC; ANTI-inflammatory agents; NONSTEROIDAL anti-inflammatory agents; TREATMENT of surgical complications; POSTOPERATIVE care; POSTOPERATIVE pain treatment
- Publication
Revista ADM, 2013, Vol 70, Issue 3, p126
- ISSN
0001-0944
- Publication type
Article