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- Title
Distribution of 3-hydroxy oxylipins and acetylsalicylic acid sensitivity in Cryptococcus species.
- Authors
Pohl, Carolina H.; Botes, Piet J.; van Wyk, Pieter W. J.; Sebolai, Olihile M.; Mzizi, Refilwe; Swart, Chantel W.; Kock, Johan L. F.
- Abstract
Using a well tested antibody specific for 3-hydroxy oxylipins, we mapped the presence of these oxylipins in selected Cryptococcus (Filobasidiella) species. Immunofluorescence microscopy studies revealed that these compounds are deposited on cell wall surfaces, appendages, and collarettes. In vitro studies revealed that growth of Cryptococcus species was inhibited by acetylsalicylic acid (which is known to inhibit mitochondrial function, including the production of 3-hydroxy oxylipins) at concentrations as low as 1 mmol/L. The results suggest that acetylsalicylic acid is effective in controlling the growth of tested pathogens, probably by targeting their mitochondria. This study further expands the known function of this anti-inflammatory drug as anti-fungal agent.
- Subjects
ASPIRIN; ANALGESICS; NONSTEROIDAL anti-inflammatory agents; SALICYLIC acid; IMMUNOGLOBULINS; IMMUNOCYTOCHEMISTRY; PATHOGENIC microorganisms; IMMUNOFLUORESCENCE; CRYPTOCOCCUS
- Publication
Canadian Journal of Microbiology, 2008, Vol 54, Issue 2, p111
- ISSN
0008-4166
- Publication type
Article
- DOI
10.1139/W07-116